FL114: Senior Research Associate, Genomics

Flagship Pioneering, Inc. · Cambridge, MA USA

  • Senior
  • Full-time
  • $81,000 – $107,250
  • Posted 2026-11-05
  • Confirmed live on 10 November 2026

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Job description

About FL114

FL114 is an innovative, privately held biotechnology company developing our novel epigenetic editing platform to treat a variety of diseases through precise, tunable modification of gene expression. FL114 was founded by Flagship Pioneering, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. With a strong emphasis on innovation and experimental execution, FL114 cultivates a highly dynamic and entrepreneurial environment.

About the Role:

FL114, Inc. is seeking an outstanding Senior Research Associate to join our Genomics team. We’re looking for a skilled, NGS-focused molecular biologist to assist in the development and advancement of our epigenetic editing programs, from early discovery research to preclinical development and beyond. The successful candidate will be an essential member of a close-knit team of experimental and computational scientists. We are looking for enthusiastic, detail oriented, adaptive, and highly motivated individuals with a passion for bringing novel medicines to patients. Applicants should be comfortable working on a fast-paced, cross-functional scientific team.

Key Responsibilities:

• Execution of NGS-based functional genomics assays in a high-throughput production environment that address core R&D needs in cell state mapping and therapeutic molecular validation

• Collaborate with research teams to help develop and support fit-for-purpose NGS solutions and molecular and cellular assay technologies

• Contribute to the development and execution of specialized molecular assays

Required Skills:

• 2+ years of hands-on experience performing NGS library prep for Illumina platforms

• Familiarity with ATAC-seq, RNA-seq, ChIP-seq, Methyl-Seq, and/or 10X Single-cell

• Direct experience operating Illumina instruments

• Familiarity with liquid handlers and Kingfisher automation

• Proficiency with quantification/QC platforms (Qubit, TapeStation/BioAnalyzer)

• Hands-on experience with core molecular biology techniques such as nucleic acid extraction/purification, PCR/qPCR, restriction digestion/ligation

• Comfortable troubleshooting and optimizing assays/protocols

• Experience in an industrial, drug-development environment preferred

• Experience in immunological indications preferred

About Flagship

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligat

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