Senior Manager, Sample Management

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

•
Provide direct, hands-on leadership to sample management staff, including daily work assignment, prioritization, and real-time problem solving.

•
Lead and participate in core sample management activities, including sample receipt, storage, tracking, retrieval, and disposal.

•
Ensure smooth day-to-day operation of automated storage systems, LIMS, and supporting laboratory infrastructure.

•
Train, mentor, and develop staff through on-the-job coaching, feedback, and performance management.

•
Develop, maintain, and enforce SOPs and best practices for all critical sample management processes.

•
Identify and implement process improvements to enhance efficiency, reliability, and scalability.

•
Serve as the primary point of contact for cross-functional partners, ensuring timely and accurate delivery of materials.

•
Work closely with the Director of Sample Management to communicate capacity, risks, and resource needs.

•
Support onboarding and ramp-up of new staff and technologies within the laboratory.

•
Provide technical leadership and subject matter expertise in tissue culture, including aseptic technique, routine cell line maintenance, culture optimization, cryopreservation, thawing, and recovery.

•
Lead the design and execution of fit-for-purpose cell banking strategies, including the creation, expansion, characterization, qualification, release, use, and retirement of research, master, and working cell banks.

•
Plan and oversee cell bank expansion activities, including seed-train design, passage management, scale-up scheduling, resource allocation, and assessment of growth, viability, and recovery performance.

•
Establish and maintain cell bank inventory controls that ensure unique identification, accurate storage locations, complete metadata, chain of custody, inventory reconciliation, capacity planning, and full lifecycle traceability.

•
Define and enforce contamination-control practices for tissue culture operations, including segregation strategies, biosafety requirements, cleaning and disinfection procedures, and appropriate response to contamination events.

•
Oversee cell bank quality assessments, including cell identity or authentication, sterility, mycoplasma status, viability, morphology, purity, and other program-specific acceptance criteria.

•
Provide expert troubleshooting for tissue culture and cell banking issues, investigate deviations and performance trends, determine root cause, and implement effective corrective and preventive actions.

•
Ensure cell culture and cryogenic equipment, including biological safety cabinets, incubators, controlled-rate freezers, and liquid nitrogen storage systems, is appropriately qualified, monitored, maintained, and fit for intended use.

•
Partner with research teams to forecast cell line demand, prioritize banking and expansion work, establish service levels, and deliver qualified cell stocks that meet program timelines.

•
Lead technical transfer, method standardization, and training for tissue culture and cell banking processes, including oversight of external vendors or contract laboratories when applicable.

Required Skills, Experience and Education:

•
BS/MS or equivalent degree in chemistry, biology, engineering, or a related scientific discipline.

•
5-10 years experience in sample management, compound management, or laboratory operations.

•
Proven experience directly supervising and leading technical staff in a laboratory environment.

•
Hands-on experience with automated sample storage systems, LIMS, and laboratory automation tools.

•
Strong attention to detail, operational discipline, and commitment to data integrity.

•
A proven background in continuous improvement methodologies.

•
Comfort operating in a fast-paced, collaborative discovery environment.

•
Clear and effective written and verbal communication skills.

Preferred Skills:

•
Experience supporting small-molecule drug discovery programs.

•
Experience training and mentoring early-career scientists or technicians.

•
Exposure to process improvement initiatives or system implementations.

•
Familiarity with vendor-managed laboratory au

Prepare for the interview

Nothing collected for this employer yet. The Blind 75 is what technical screens draw from; practise it here, with a coach, in Java or Python.

More at Revolution Medicines

• Executive Director, US Portfolio Analytics · Redwood City, California, United States
• Senior Research Associate, DMPK · Redwood City, California, United States
• Senior Administrative Assistant II, Commercialization · Redwood City, California, United States
• Director, Drug Product · Redwood City, California, United States
• Contract Administrator III · Redwood City, California, United States
• Senior Administration Assistant · Redwood City, California, United States
• Associate Director, Payroll, Europe · Basel, Switzerland
• Principal Product Manager, Chemistry · Redwood City, California, United States