Principal Product Manager, Chemistry

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

We are seeking a Principal Product Manager, Chemistry to deliver products and capabilities that help Chemistry teams make faster, higher-confidence design and progression decisions in oncology-focused drug discovery.

This role will define and deliver the product strategy for Chemistry workflows, data products, and AI-enabled decision support using the right mix of internal product development, SaaS platforms, vendor partnerships, integrations, and RevCore capabilities. You will partner with medicinal chemists, synthetic chemists, computational chemists, analytical chemists, DMPK and Biology partners, Data Science, ML Engineering, Data Engineering, IT, and platform teams to turn complex Chemistry workflows into intuitive, scalable solutions that accelerate the Design-Make-Test-Learn cycle.

Own Chemistry product strategy

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Define the vision and roadmap for Chemistry products and capabilities across medicinal chemistry, synthetic chemistry, analytical chemistry, compound management, and the Design-Make-Test-Learn cycle.

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Build a Now, Next, Later roadmap from foundational compound data capabilities to self-service analytics, model-supported design, and AI-enabled decision support.

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Set success metrics tied to trusted compound data access, reduced manual data preparation, faster design cycles, compound progression decisions, and scientific adoption.

Shape product solutions around Chemistry workflows and decisions

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Understand workflows for medicinal chemists, synthetic chemists, computational chemists, analytical chemists, compound management teams, and cross-functional program teams.

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Design solutions around key decision moments such as compound design, analog selection, route selection, synthesis planning, SAR interpretation, multi-parameter optimization, compound triage, and program prioritization.

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Translate Chemistry workflows into clear product requirements, evaluation criteria, user stories, and prioritized capabilities.

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Determine when to build, buy, partner, or integrate based on user needs, market capabilities, scalability, differentiation, interoperability, and long-term maintainability.

Establish trusted, reusable Chemistry capabilities and data products

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Partner with technical teams, vendors, and SaaS providers to deliver priority Chemistry capabilities across RevCore and core Chemistry platforms.

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Clarify trusted sources and systems of record for key Chemistry data, including compounds, structures, batches, lots, reactions, routes, analytical results, assay results, and calculated properties.

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Improve structured data capture, data quality, metadata, and usability across Benchling, D360, legacy CDD data, compound registration, analytical systems, inventory systems, and related Chemistry platforms.

Enable self-service discovery, AI use cases, and adoption

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Enable self-service access, compound search, structure search, SAR exploration, semantic discovery, and “Ask your Chemistry data” experiences across priority datasets.

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Use modern AI, analytics, workflow, and low-code tools to prototype concepts, validate user needs, and de-risk ideas before full engineering investment.

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Partner with Data Science and ML Engineering to identify and deliver AI and GenAI use cases such as chemistry copilots, SAR summarization, analog search, compound profile generation, synthesis-aware design support, and automated annotation

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Drive rollout, adoption, and continuous improvement through usage metrics, feedback loops, training, and measurable workflow improvements.

Required Skills, Experience and Education:

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10 years of experience in Product Management, Data Product Management, Chemistry Informatics, Cheminformatics, Scientific Data Platforms, or related roles within biotech, pharma, life sciences, or another research-intensive environment.

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Strong product leadership experience, including defining vision, shaping strategy, building roadmaps, prioritizing tradeoffs, and delivering measurable outcomes.

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Deep understanding of small molecule Chemistry workflows, including medicinal chemistry, Design-Make-Test-Learn, SAR analysis, compound progression, and multi-pa

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