Executive Director, Clinical Supply Chain

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

The Executive Director, Clinical Supply Chain provides strategic leadership and operational oversight for end-to-end clinical supply chain activities across the organization.

Strategic Leadership

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Define and execute the global clinical supply chain strategy aligned with the company’s clinical development pipeline and long-term business goals.

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Establishes strategies and processes to ensure uninterrupted supply for Revolution Medicines portfolio across all phases of development.

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Lead and serve as subject matter expert for clinical supply chain planning, risk management, and execution of clinical supply chain activities.

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Build scalable processes and infrastructure to support early- through late-phase clinical programs.

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Strategic Planning on comparator sourcing management to ensure timely, compliant and cost-effective product availability.

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Effective management of clinical studies executed in conjunction with collaboration partners.

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Identify and implement overall clinical supply chain best practices.

Clinical Supply Operations

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Oversee end-to-end clinical supply activities, including demand forecasting, protocol reviews, packaging, labeling, distribution, and returns.

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Ensure uninterrupted supply of investigational medicinal products (IMP), including RevMed and comparator products.

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Champions monthly Development Operations planning (DnOP) process in collaboration with PDM and Clinical Operation team members.

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Ensures efficient global clinical supply chain distribution networks are in place.

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Oversee comparator products demand and supply planning with expert level knowledge in comparator drugs and co-medications sourcing strategy

Cross-Functional Collaboration

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Partner with Clinical Operations and Clinical Study Execution Teams (CSET) in study planning and execution.

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Collaborate with PDM, Quality, and Regulatory to ensure compliant manufacturing, labeling, and distribution

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Work closely with Finance on budgeting, forecasting, and cost optimization.

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Work effectively with internal and external partners to develop sound strategies, identify and mitigate risks, and resolve issues as they arise.

Compliance & Quality

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Ensure all clinical supply activities comply with GxP, ICH, FDA, EMA, and global regulatory requirements.

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Expert knowledge of applicable GxP requirements and applicable regulatory guidances.

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Lead inspection readiness activities as required for global filings and maintain and inspection ready organization.

Team Leadership

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Build, lead, and mentor a high-performing clinical supply chain organization. Drives for excellence in execution of agreed upon strategies.

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Establish clear performance metrics, development plans, and succession planning.

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Foster a culture of accountability, continuous improvement, and collaboration.

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Drives excellence in setting clear and actionable team goals.

Required Skills, Experience and Education:

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Bachelor’s degree in Supply Chain, Business, Engineering or Life Sciences with 20+ years of experience in pharmaceutical supply chain. Master’s degree (MS, MBA) with at least 18 years of experience in pharmaceutical/biotech supply chain.

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CPIM/CSCP certifications a plus.

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At least 5 years of experience in a leadership/supervisory role.

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Strong knowledge and experience with cGMP operations for small molecules, end- to end supply chain and demand/supply planning.

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Effective vendor management and oversight skills

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Excellent cross-functional leadership skills with effective communication skills.

Preferred Skills:

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Proven leadership experience hiring, managing and developing teams.

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Knowledge and experience with outsourced manufacturing operations. (CMO’s)

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Effective, open and transparent communication skills (verbal and written). Strong analytical, communication and executive level reporting skills.

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Capable of working on multiple projects/tasks and able to meet timelines.

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Self-starter with a high-level of comfort with ambiguity and complexity and the ability to multi-task while consistently delivering quality results.

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Team-oriented, progressive thinker who enjoy

Prepare for the interview

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