Sr. Product Manager, Lab Execution CGP (Oncology)

Natera · San Carlos, CA

  • Senior
  • Full-time
  • $154,600 – $193,300
  • Posted 2026-11-09
  • Confirmed live on 10 November 2026

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Job description

Sr. Product Manager, Lab Execution CGP (Oncology)

About the Role

This is your chance to own the product vision for the software that runs Natera's Comprehensive Genomic Profiling (CGP) labs. From extraction through library prep, sequencing, and assay QC, the platforms you shape will power tissue and liquid CGP testing at scale, and help oncologists make faster, better-informed treatment decisions for their patients. The work is complex, the stakes are high, and your customers are on the lab floor every day.

You will work with a team of engineers and partner shoulder-to-shoulder with Engineering, Lab Operations, R&D, Automation, and Bioinformatics to turn ambitious launch and scale goals into software lab scientists love using. You will set the strategy, make the hard trade-offs, and stay close enough to the details to untangle the edge cases that make CGP workflows hard, like combo orders, fallbacks, and reworks. With a "do more with less" mindset, you will put AI to work across both the product and the PM craft, and lead with clarity and kindness.

Key Responsibilities

Product Strategy & Vision

• Own the product strategy and roadmap for Lab Execution software in our CGP labs spanning across extraction, library prep, sequencing, and assay QC.

• Translate Oncology business goals (launch timelines, volume growth, turnaround time, and COGS) into a prioritized, outcome-driven roadmap.

• Drive a platform mindset: reusable, configurable capabilities that serve multiple assays and labs instead of one-off builds.

• Champion AI-forward products that reduce manual touchpoints, surface exceptions early, and make lab operators more effective.

Product Execution & Delivery

• Own end-to-end delivery for new CGP assay launches and enhancements: requirements, UAT, lab process verification and validation, go-live, and hypercare.

• Build deep relationships with lab operations through on-sites, recurring feedback sessions, and rapid prototyping.

• Turn business, clinical, and lab requirements into clear epics, user stories, and acceptance criteria that engineering teams can execute on.

• Prioritize backlogs with engineering leaders, balancing new capabilities, operational quality-of-life improvements, and technical debt.

• Define and track KPIs such as turnaround time, throughput, failure and rework rates, manual touchpoints, and adoption, and use them to steer investment.

• Partner with Quality and Regulatory to ensure products meet CLIA/CAP, 21 CFR Part 11, design control, and LDT/IVD requirements.

Cross-Functional Leadership

• Be the primary product partner to Lab Operations, R&D, Automation, Bioinformatics, and Oncology product leadership.

• Communicate roadmaps, trade-offs, and risks crisply to senior leadership, and build alignment across competing priorities.

• Coordinate with adjacent product areas (LIMS, ordering, bioinformatics pipelines, reporting, and MRD Lab Execution) for a seamless sample-to-report experience.

• Spend real time on the lab floor to build deep empathy for the people using your products.

Qualifications

Required Skills & Experience

• A track record of shipping complex, workflow-heavy software for high-complexity labs (LIMS/LES/LIS), healthcare, or other regulated domains.

• Experience taking products from zero to one and scaling them to high volume.

• Strong understanding of NGS laboratory workflows; oncology or CGP experience strongly preferred.

• Experience in regulated environments.

• Data-driven decision maker, comfortable with SQL, dashboards, and making quantitative arguments for product direction.

• Fluency in Agile (Scrum/Kanban) and hands-on experience with Jira and Confluence.

• Excellent communication and stakeholder management skills, with the ability to influence without authority, from lab technicians to executives.

Nice to Have

• Direct experience with tissue and/or liquid CGP assays, histology, or IHC workflows.

• Experience with lab automation and instrument integration (liquid handlers, sequencers).

• Experience building AI/ML-powered features or using AI to scale product teams.

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

•
Annual performance incentive bonus

•
Long-term equity awards

•
Comprehensive health benefits (medical, dental, vision)

•
401(k) with company match

•
Generous paid time off and company holidays

•
Additional wellness and work-life benefits

Compensation Range
$154,600—$193,300 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the st

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