Research Investigator / Senior Research Investigator (In-vitro Pharmacology, Exploratory Sciences), London

Job description

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

About the Exploratory Sciences Team

You will be joining the expanding “Exploratory Sciences” team, focused on tackling proteins which are critical for disease biology, but have been traditionally considered intractable.

We are a multidisciplinary team within the Drug Design and Medical Research function at Isomorphic Labs. We work where machine learning, chemical biology and drug discovery meet, applying the Isomorphic Labs platform to some of the hardest problems in the field.

Our work goes beyond individual targets. We explore emerging therapeutic modalities, molecular glues and peptides to modalities that don't have a playbook yet. We also design the data generation strategies that make these modalities workable for AI-driven design. The experiments we run don't just move drug-discovery programmes forward - they shape the models that power Iso's drug design engine.

We're as comfortable in silico as we are at the bench. Our scientists build and test hypotheses computationally, use LLM-based agentic workflows in their daily science, and work alongside ML researchers and engineers on Platform builds. We work closely with teams across Isomorphic Labs, so ideas move quickly from model to real world experiments and back again, keeping the goal of drug discovery and development front and centre.

Above all, we're curious and ambitious, and we care about growth. We put continuous learning and development first, because we're building the next generation of drug discovery scientists. If you want to help define what drug discovery looks like next, you'll fit right in.

Your impact

We're looking for a talented, hands-on in vitro pharmacologist to join Exploratory Sciences and help turn bold ideas about new therapeutic modalities into robust experimental data.

You'll be the experimental engine behind our exploratory programmes. You'll design, build and run the biochemical, biophysical and cellular assays that tell us whether a new modality works. You'll also help define what good data looks like when there's no established playbook.

You'll make the data count twice. Every experiment you design should move a programme forward and also make our models smarter. Working closely with ML and computational colleagues, you'll help find the places where the platform has blind spots and come up with new assays that fill them.

You'll be part of a new way of doing biology. You'll use LLM agentic workflows and in silico hypothesis building in your everyday science, and help shape the tools you and your colleagues depend on.

Ready to take the next step in your scientific career? Isomorphic Labs gives ambitious scientists a unique place to take on stimulating challenges, push their boundaries and accelerate their personal and professional growth.

What you will do

Assay Development & Experimental Execution:

• Design, develop and run biochemical, biophysical (e.g. SPR/GCI, nanoDSF, Spectral Shift, MST) and cellular assays for novel modalities.

• Generate quantitative data on binding kinetics, ternary complex formation, degradation

Prepare for the interview

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